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FOR RESEARCH
FOR RESEARCH
Relative abundance, and acid-base properties of the natural amino acids.
| Amino acid | Codes | Relative abundance (mole%) (1) | MW (2) | pKa (3) |
|---|---|---|---|---|
| Parental | ||||
| Glycine | gly G | 8.3 | 57.05 | |
| Aliphatic | ||||
| Proline | pro P | 3.4 | 97.12 | |
| Alanine | ala A | 9.4 | 71.09 | |
| Valine | val V | 5.8 | 99.13 | |
| Leucine | leu L | 10.7 | 113.08 | |
| Isoleucine | ile I | 5.7 | 113.16 | |
| Aromatic | ||||
| Phenylalanine | phe F | 4.8 | 147.18 | |
| Tryptophan | trp W | 1.1 | 186.21 | |
| Tyrosine | tyr Y | 2.9 | 163.18 | 9.6 |
| Histidine | his H | 2.1 | 137.14 | 7.0 |
| Sulfur | ||||
| Cysteine | cys C | 2.5 | 103.15 | 8.5 |
| Methionine | met M | 2.3 | 131.20 | |
| Hydroxyl | ||||
| Serine | ser S | 7.4 | 87.08 | 16 |
| Threonine | thr T | 5.5 | 101.11 | 16 |
| Strongly acidic | ||||
| Aspartic acid | asp D | 4.6 | 115.09 | 4.7 |
| Glutamic acid | glu E | 5.3 | 129.16 | 12 |
| Strongly basic | ||||
| Lysine | Iys K | 5.6 | 128.17 | 10.2 |
| Arginine | arg R | 4.6 | 156.19 | 12 |
| Amido | ||||
| Aspargine | asn N | 4.3 | 114.10 | |
| Glutamine | gln Q | 3.7 | 128.13 |
(1) Analysis of 9 proteins: insulin (bovine), lysozyme (chicken), mannitol permease & lactose permease
(E. coli), hemoglobin & cytochrome c (human), glucagon (pig), ferridoxin (spinach), wool (sheep).
(2) Isotopic average of neutral amino acyl residu in a peptide bond.
(3) In peptides in aqueous solution. N-terminus: pKa=7.8 & C-terminus: pKa=3.7.