Una selección de los trabajos publicados que han utilizado péptidos, anticuerpos, genes sintéticos o proteínas recombinantes producidos por Genosphere Biotechnologies.


Selected articles

 

Enolase of Staphylococcus lugdunensis is a surface-exposed moonlighting protein that binds to extracellular matrix and the plasminogen/plasmin system. 

Hussain, M. et al. (2022).  Frontiers in Microbiology, 13.

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Keywords: adhesion, enolase, glycolysis, moonlighting proteins, plasminogen plasmin system, Staphylococcus lugdunensis, coagulase-negative staphylococci, extracellular matrix proteins

 

Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p) ppGpp.

Czech, L. et al. (2022).  Nature Communications 13, 1069.

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Keywords:  nucleotide-based second messengers, (p)ppGpp, signal recognition particle , SRP

 

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity towards the autophagy-related hATG8 proteins. 

Brennan, A. et al. (2022). Journal of Biological Chemistry 298, p.101514.

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Keywords:  AIM; SQSTM1/p62; amyotrophic lateral sclerosis; autophagy; hATG8.

 

Synthetic Melanin Acts as Efficient Peptide Carrier in Cancer Vaccine Strategy.

Cuzzubbo, S. et al. (2022).  International Journal of Molecular Sciences 23, p14975.

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Keywords: melanin; L-DOPA; cancer vaccine; adjuvant; nanoparticles; carrier; delivery system; peptide vaccine; dendritic cells; Langerhans cells.

 

Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. 

Talbot-Cooper, C. et al. (2022). Cell Host & Microbe 30, p357.

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Keywords:  poxvirus, paramyxovirus, vaccinia virus, Nipah virus, immune evasion, IFN signaling, STAT1, virulence factor, co-structure, convergent evolution.

 

PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders. 

Manso, J. A. et al. (2022).  Cellular and Molecular Life Sciences 79, p131.

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Keywords: Immunology, Pyogenic arthritis, pyoderma gangrenosum, myeloid-related proteinemia inflammatory syndrome, PAPA, PAMI, Auto-inflammation, LYP, PSTPIP1, F-BAR domain

 

Connexin Hemichannel Activation by S-Nitrosoglutathione Synergizes Strongly with Photodynamic Therapy Potentiating Anti-Tumor Bystander Killing.

Nardin, C., et al. (2021) Cancers, 13(20), p.5062.

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Keywords:  photosensitization, nitric oxide, purinergic signaling, calcium signaling

 

Proposed mechanism for regulation of H2O2‐induced programmed cell death in plants by binding of cytochrome c to 14‐3‐3 proteins.

ElenaReal, C.A., et al. (2021) The Plant Journal, 106(1), pp.74-85.

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Keywords:  14-3-3 protein family; Arabidopsis; ITC; NMR; cytochrome c; programmed cell death.

 

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Shorrocks, A.M.K., et al. (2021) Nature communications, 12(1), pp.1-15.

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Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.

Campion, R., et al. (2021) Biochemical Journal, 478(24), pp.4153-4167.

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Keywords:  Saccharomyces cerevisiae; aging; mitochondria; molecular chaperones.

 

Rapid viscoelastic changes are a hallmark of early leukocyte activation.

Zak, A., et al. (2021) Biophysical Journal, 120(9), pp.1692-1704.

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Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R.

Gellrich, A., et al. (2021) Frontiers in molecular biosciences, 8, 702341

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Keywords:  metalloprotease, meprin, sheddase, IL-6, CD99, APP, ADAM

 

Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule.

Cabrero, P., et al. (2020) Proceedings of the National Academy of Sciences, 117 (3) 1779-1787

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Keywords:  Drosophila melanogaster; Malpighian tubule; Xenopus oocyte; aquaporin; stellate cell

 

Comparative proteome and metabolome analyses of latex-exuding and non-exuding Taraxacum koksaghyz roots provide insights into laticifer biology.

Benninghaus, V.A., et al. (2020) Journal of experimental botany, 71, pp.1278-1293.

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Keywords:  Articulated laticifers, barnase/barstar, differentially accumulated proteins, latex-non-exuding phenotype, metabolomics, proteomics, Taraxacum koksaghyz

 

Connexin43 hemichannel targeting with TAT-Gap19 alleviates radiation-induced endothelial cell damage.

Ramadan, R., et al. (2020) Frontiers in Pharmacology, 11, 212

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Keywords: atherosclerosis, endothelial damage, ionizing radiation, connexin43 hemichannels, TAT-Gap19

 

Ultrastructural characterization of mitochondrial damage in experimental autoimmune neuritis.

Muke, I., et al. (2020) Journal of Neuroimmunology, 343, p.577218.

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Keywords:  Schwann cell, axon, mitochondria, neuritis, neuroinflammation ;

 

Role of SrtA in Pathogenicity of Staphylococcus lugdunensis

Hussain, M., et al. (2020) Microorganisms, 8(12), p.1975.

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Keywords:  LPXTG; Staphylococcus lugdunensis; sortase A; surface proteins.

 

Anxiolytic Activity and Brain Modulation Pattern of the α-Casozepine-Derived Pentapeptide YLGYL in Mice.

Benoit, S., et al. (2020) Nutrients, 12(5), p.1497.

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Keywords: milk bioactive peptide; α-Casozepine; anxiolytic; proteolytic fragments; anxiety; neuronal activity modulation; c-Fos

 

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.

Sogues, A., et al. (2020) Nature communications, 11(1), pp.1-14.

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Analysis of genes within the schizophrenia-linked 22q11. 2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control.

Maurer, G.W., et al. (2020) PLoS genetics, 16(4), p.e1008727.

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Keywords:  human 22q11.2 deletion syndrome ; 22q11.2 DS ; schizophrenia ; sleep ; gene LZTR1 ; night owl ; nowl ; Drosophila ; Neurofibromin-1 deficiency ; Nf1 ; GABA signaling ; metabolic homeostasis

 

The adjuvant effect of melanin is superior to incomplete Freund’s adjuvant in subunit/peptide vaccines in mice.

Cuzzubbo, S., et al. (2020) Cancer Immunology, Immunotherapy, 69(12), pp.2501-2512.

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Keywords:    Cancer vaccine, Immunotherapy, Synthetic melanin, Neoepitope mAdpgk, PD1, Peptide vaccine, Adjuvant, TLR9 agonist, CD8 + T-cell responses, MC38 model,

 

Structure of the Lifeact–F-actin complex.

Belyy, A et al. (2020) PLoS biology, 18(11), p.e3000925.

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Keywords: Actin-binding peptide ; Lifeact–F-actin complex; cryo-EM, electron cryo-microscopy; F-actin, filamentous actin; cofilin ;  myosin ; actin-binding toxins, ; TccC3HVR ; TccC3

 

 

Meprin β: A novel regulator of blood–brain barrier integrity.

Gindorf, M., et al. (2020) Journal of Cerebral Blood Flow & Metabolism, 41(1), pp.31-44.

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Keywords:  Blood–brain barrier, meprin β, tight junctions, brain endothelium, brain water content, metalloprotease, Mep1b

 

Staphylococcus aureus-derived α-hemolysin evokes generation of specialized pro-resolving mediators promoting inflammation resolution.

Jordan, P.M., et al. (2020) Cell reports, 33(2), p.108247

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Keywords:  lipid mediator, specialized pro-resolving mediators, lipoxygenase, inflammation, pore-forming toxin, α-hemolysin, Staphylococcus aureus

 

 

Deciphering CD4+ T cell specificity using novel MHC-TCR chimeric receptors.

Kisielow, J., et al. (2019) Nature immunology, 20(5), pp 652-662

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Keywords: αβ T cell cognate peptides ; αβ T cell antigen receptors ; TCRs ; natural epitopes of CD4+ T cells ; peptide vaccination ; tumor-infiltrating lymphocytes

 

Peptides derived from the extracellular domain of the somatostatin receptor splicing variant SST5TMD4 increase malignancy in multiple cancer cell types.

del Rio-Moreno, et al. (2019) Translational Research, 211, pp.147-160.

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Keywords:  tumor pathologies; SST1-5; somatostatin receptor 5 variant with 4 transmembrane domains; hepatocellular carcinoma; neuroendocrine tumor ; SST5TMD4-derived peptides ; somatostatin receptor subtype-5 ; truncated variant

 

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Leimbacher, P.A., et al. (2019) Molecular cell, 74(3), pp 571-583

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Keywords:  MDC1 TOPBP1 complex ; casein kinase 2 ; CK2 ; DNA damage response ; DSBs in mitosis ; mitotic radiosensitivity ; chromosomal instability ; micronuclei formation ; chromosome end-to-end fusions.

 

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.

Montaldo, N.P., et al. (2019) Nature communications, 10(1), pp.1-13.

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Keywords:  Actively transcribing chromatin; RNA pol II; Elongator complex; ELP1 subunit; aberrantly methylated DNA bases; 7-methylguanine; 3-methyladenine; Base excision repair; BER; alkyladenine DNA glycosylase; AAG; aberrant DNA bases

 

Synthetic peptides as a novel approach for detecting antibodies against sand fly saliva.

Sima, M., et al. (2019) PLoS neglected tropical diseases, 13(1), p.e0007078.

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Keywords:  Leishmania transmission, salivary antigens, Phlebotomus orientalis, Leishmania donovani, yellow-related protein, ParSP25-like protein.

 

NEP-TC a rRNA Methyltransferase Involved on Somatic Embryogenesis of Tamarillo (Solanum betaceum Cav.).

Correia, S.I., et al. (2019) Frontiers in Plant Science, 10, p.438.

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Keywords:  Somatic embryogenesis induction ; somatic embryo development ; SpoU rRNA methylase family ; tamarillo;  Solanaceae family ; plant morphogenesis

 

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.

Corman, A., et al. (2019) Cell chemical biology, 26(2), pp 235-243

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Keywords: ALS; BET Bromodomain; C9ORF72; arginine-rich peptides; chemical screen; dipeptide repeat proteins; nucleolar stress; sodium phenylbutyrate; zebrafish; poly(PR) peptides; non-ATG translation; dipeptide repeats; DPRs; HDAC inhibitors; PFI-1.

 

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.

Peters, F., et al. (2019) The FASEB Journal, 33(6), pp 7490-7504

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Keywords:  chronic intestinal inflammation; meprin β; protease; human meprin heterodimers; meprin α / meprin β-enzyme complex; meprin-knockout mice.

 

SIPA1L2 controls trafficking and signaling of TrkB-containing amphisomes at presynaptic terminals.

Andres-Alonso, M., et al. (2019) Nature Communications, 10(1):5448

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Keywords: Amphisomes, autophagy pathway, autophagosomes, endosomes, neurons BDNF/TrkB, RapGAP, dynein motor, hippocampal neurons, presynaptic plasticity

 

PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria.

Liu, D., et al. (2019) Mitochondrion, 47, pp.64-75.

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Keywords:  phosphodiesterase ; cAMP-degrading enzymes ; Calcium ; cAMP ; Mitochondrial membrane potential ; rodent cardiac mitochondria ; PDE2 transgenic mice ; oxidative phosphorylation ; subsarcolemmal mitochondria

 

Optimization of peptide-based cancer vaccine compositions, by sequential screening, using versatile liposomal platform.

Jacoberger-Foissac, C., et al. (2019) International journal of pharmaceutics, 562, pp 342-350

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Keywords:  Liposome ; Therapeutic vaccination ; Cancer vaccine; Adjuvant ; PRR agonists ; Peptide-based vaccine ; CD4 epitope peptide ; CD8 tumor-specific epitope peptide ; Pattern recognition receptors ; HA influenza virus peptide ; HPV16 E7 oncoprotein peptide; TLR4, TLR2/6 , NOD1 agonists

 

Integrin α6β4 recognition of a linear motif of bullous pemphigoid antigen BP230 controls its recruitment to hemidesmosomes.

Manso, J.A., et al. (2019) Structure, 27(6), pp.952-964.

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Keywords:  hemidesmosomes ; integrin α6β4 and BP230 ; β4 - BP230 Crystal structure; FnIII domains ; cell adhesion ; keratinocytes plakins ; intermediate filaments.

 

Feline Infectious Peritonitis as a Systemic Inflammatory Disease: Contribution of Liver and Heart to the Pathogenesis.

Malbon, A.J., et al. (2019) Viruses, 11(12), p.1144.

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Keywords: feline infectious peritonitis; feline coronavirus; hepatocytes; cardiomyocytes; inflammatory cytokines; pathogenesis; systemic inflammatory response, IL-1β, IL-6, TNF-α

 

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.

Delvaeye T., et al. (2019) Scientific reports, 9(1), pp.1-12.

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Keywords:  Cx43 hemichannels; TAT-Gap19; TAT-CT9; Gap27; renal vascular permeability ; TNF-induced SIRS; tumour necrosis factor; systemic inflammatory response syndrome

 

Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis.

Romp, E., et al. (2019) Cellular and Molecular Life Sciences, 77(19), pp.3841-3858.

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Keywords:  5-Lipoxygenase; Exotoxins; Leukotriene; Phenol-soluble modulins; Staphylococcus aureus, neutrophil infiltration, infectious inflammation, chemotactic, LTB4, 5-LOX, pore-forming toxin α-hemolysin, PSM Peptides

 

The nitrogen regulator PipX acts in cis to prevent operon polarity.

Cantos, R., et al. (2019) Environmental microbiology reports, 11(4), pp.495-507.

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Keywords:  Cyanobacteria, Bicistronic pipXY operon, PipX , NusG, TLD/KOW domain, pipY expression, PipX-PipY stoechiometry

 

The SRP signal sequence of KdpD.

Pross, E. and Kuhn, A. (2019) Scientific Reports, 9(1), p.8717.

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Keywords:  Walker A motif; KdpD signal sequence; ATP binding sites; cytoplasmic signal recognition particle; SRP receptor protein FtsY.

 

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.

Qu, Y., et al. (2019) eLife, 8, e50319

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Keywords:  ARF activator Efa6, Cortical collapse factors, Drosophila Efa6, MT elimination domain, axon growth regulation, MTED

 

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila.

Zandawala, M. et al. (2018)   Cellular and Molecular Life Sciences, 75(6), pp.1099-1115.

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Keywords:  Diuretic hormone 44 ; Corticotropin-releasing factor-like diuretic hormone ; Leucokinin ; Peptide hormones ; Stress resistance

 

Host-Polarized Cell Growth in Animal Symbionts.

Pende, N. et al. (2018)   Current biology, 28(7), pp.1039-1051.

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Keywords:  Cell growth ; cell division ; cell shape ; symbiosis ; peptidoglycan ; MreB ; FtsZ ; Gammaproteobacteria

 

Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation.

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Sajic, M. et al. (2018)   Journal of neuroinflammation, 15(1), p.61.

Keywords:  Experimental autoimmune neuritis (EAN) ; Phototoxic damage ; In vivo Confocal imaging ; Mitochondrial ; Small axons ; Pain ; Neuropathy

 

The neurofilament derived-peptide NFL-TBS. 40-63 enters in-vitro in human neural stem cells and increases their differentiation.

Barreau, K. et al. (2018)   PloS one, 13(8), p.e0201578.

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Keywords:  neurodegenerative diseases ; rat neural stem cells

 

Control of neural crest induction by MarvelD3-mediated attenuation of JNK signalling.

Vacca, B. et al. (2018)  Scientific reports, 8(1), p.1204.

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Keywords:  Tight junctions, junctional barriers, semipermeable paracellular barriers, junctional signalling mechanisms, JNK, c-Jun N-terminal Kinase, AP1, ZONAB, YAP/TAZ, plaque proteins, cytoskeletal linkers, occludin, tricellulin, MarvelD3, junctional MARVEL domain, junctional tetraspan transmembrane proteins, epithelial stress response, eye morphogenesis, neural crest, Xenopus embryogenesis, early vertebrate development

 

 

Multivalency: Key Feature in Overcoming Drug Resistance with a Cleavable Cell-Penetrating Peptide-Doxorubicin Conjugate.

Lelle, M. et al. (2018)   International Journal of Peptide Research and Therapeutics, 24(3), pp.355-367.

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Keywords:  Cell-penetrating peptide ; Multivalency ; Drug-peptide conjugate ; MDR ; Doxorubicin ; Drug resistance

 

Inhibition of astroglial connexin43 hemichannels with TATG ap19 exerts anticonvulsant effects in rodents.

Walrave, L. et al. (2018)   Glia, 66(8), pp.1788-1804.

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Keywords:  TAT-Gap19; astrocytes; connexin43 hemichannels; pilocarpine; seizures

 

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition.

Elena-Real, C.A. et al. (2018)   Cell death & disease, 9(3), p.365.

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Phosphatidylserine-liposomes Promote Tolerogenic Features on Dendritic cells in human Type 1 Diabetes by apoptotic Mimicry.

Rodriguez-Fernandez, S. et al. (2018)   Frontiers in immunology, 9, p.253.

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Antigenic mimicry of ubiquitin by the gut bacterium Bacteroides fragilis: a potential link with autoimmune disease.

Stewart, L. et al. (2018)   Clinical and experimental immunology, 194(2), p.153.

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Keywords:  Bacteroides fragilis ; autoimmune disease; coeliac; multiple sclerosis; rheumatoid arthritis; ubiquitin; ulcerative colitis; BfUbb protein

 

The Hebeloma cylindrosporum HcPT2 Pi transporter plays a key role in ectomycorrhizal symbiosis.

Becquer, A. et al. (2018)   New Phytologist, 220(4), pp.1185-1199.

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Keywords:  Pinus pinaster; Hebeloma cylindrosporum; 32P labeling; RNA interference; X-ray fluorescence mapping; ectomycorrhizal fungus; overexpression; phosphate transporter; symbiotic interface; inorganic phosphate; Hartig net; HcPT2; ectomycorrhizal symbiosis

 

The extreme C terminus of the Pseudomonas aeruginosa effector ExoY is crucial for binding to its eukaryotic activator, F-actin. Journal of Biological.

Belyy, A. et al. (2018)   Chemistry, 293(51), pp.19785-19796.

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Keywords:  ExoY; Pseudomonas aeruginosa; F-actin; bacterial toxin; confocal microscopy; cyclic nucleotide; protein cross-linking; protein-protein interaction; type III secretion system; nucleotidyl cyclase; 3′5′-cyclic nucleoside monophosphates

 

A secreted antibacterial neuropeptide shapes the microbiome of Hydra.

Augustin, R. et al.  (2017)  Nature communications, 8(1), p.698.

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Keywords:  Colonization of body epithelial surfaces, sensory neurons, ganglion neurons, ectodermal epithelium, hydra, Cnidaria, neuropeptides, antibacterial, microbiome, NDA-1, reduction of Gram-positive bacteria, Gram-negative Curvibacter sp, β-Proteobacteria, nerve cells, homeostasis, holobiont, biologically active peptides, corals, jellyfishes, polyps, bilateria, metazoans, microbiota, bacteroidetes, antimicrobial

 

 

The leaderless bacteriocin Enterocin K1 is highly potent against Enterococcus faecium: a study on structure, target spectrum and receptor.

Ovchinnikov, K.V. et al.  (2017)  Frontiers in microbiology, 8, p.774.

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Keywords:  enterocin K1, EntK1, enterocin EJ97, EntEJ97, LsbB, bacteriocins, lactococci, Enterococcus faecium, nosocomial multidrug resistant, rseP, stress response, Zn dependent protease, Streptococcus pneumoniae, synthetic ComS peptide

 

 

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Bedau, T. et al.  (2017)  The FASEB Journal, 31(3), p.1226

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Keywords:  Adhesion molecule CD99 ; Transendothelial migration ; TEM assay ; Metalloprotease meprin β ; γ-secretase ; Intramembrane proteolysis ;  Tissue remodeling ; Inflammation ; Lewis lung carcinoma cells ; Mep1b−/− mice

 

 

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.

Weaver, R.E. et al. (2017). Biochem Pharmacol. , 127, pp. 71-81

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Keywords:  Parathyroid hormone ; PTH ; GPCR ; Agonist ; Receptor ; TIP39 ; Cancer treatment

 

 

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.

Abplanalp, J. et al.  (2017)  Nature communications, 8(1), p.2055.

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Keywords:  antibodies, histone post-translational modifications, hydrolases, ADP-ribosylation, ARTD1, PARP1, PARG, ARH3, poly-ADP-ribosylation, PARylation, mono-ADP-ribosylation, hydrogen peroxide stress, ADP-ribosylome, nicotinamide adenine dinucleotide

 

 

Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling.

Brobeil, A. et al.  (2017)  Biomolecules, 7(3), p.55.

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Keywords:  Protein–protein interactions, protein tyrosine phosphatase interacting protein 51, PTPIP51, LDC-3, regulation of the endogenous interactome, siRNA, human keratinocytes, HaCaT cells, mitogen activated protein kinase, MAPK, Raf-1, protein scaffold 14-3-3, protein tyrosine phosphatase 1B, PTP1B, dysregulated signal transduction, proliferation, differentiation, apoptosis, basal cell carcinoma, squamous cell carcinoma, acute myeloid leukemia, malignant blasts, EGFR, insulin receptor, nuclear factor κB, transcription factors, NFκB, neurophysin, CGI-99, Nuf2, DGKα, c-Src, mitotic protein complex, calcium homeostasis

 

 

Phytochelatin synthesis in response to Hg uptake in aquatic plants near a chlor-alkali factory.

Turull, M. et al.  (2017)  Chemosphere, 176, pp.74-80.

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Keywords:  Ceratophyllum demersum; Mercury; Myriophyllum spicatum; Phytochelatins

 

 

The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box.

Kilkenny, M.L. et al.  (2017)  Open biology, 7(11), p.170217.

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Keywords:  Ctf4-interacting peptide (CIP) motif, DNA replication, replisome, protein–protein interactions, protein–DNA interactions, DNA polymerase, protein hub, Ctf4, chromosome transmission fidelity 4, DNA helicase, Cdc45-MCM-GINS, CTF4 orthologue, AND-1, DNA polymerase α, Pol α / primase, helicase–nuclease Dna2, SepB domain, HMG box, lagging-strand, replication fork, human replisome, Chl1, rDNA, Tof2

 

 

GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T cell responses leading to tumor regression.

Esquerré, M. et al.  (2017)  PloS one, 12(3), e0174038.

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Keywords:  HPV-16 ; Mouse models ; T cells Cytotoxic T cells ; Vaccination and immunization ; Human papillomavirus infection ; Immunologic adjuvants ; Cancer treatment

 

 

A role for the metalloprotease invadolysin in insulin signaling and adipogenesis.

Chang, C.W. et al.  (2017)  Biological Chemistry, 398(3), pp.373-393.

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Keywords: adipogenesis; insulin signaling; lipid droplets; metalloprotease ; Invadolysin ; metazoans ; Drosophila ; glycogen storage ; autophagy

 

 

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface.

Bestgen, B. et al.  (2017)  Pharmaceuticals, 10(1), p.16.

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Keywords:  cell death; cyclic peptides; protein kinase CK2; protein–protein interaction; subunit interface

 

 

Structural Insight into BLM Recognition by TopBP1.

Sun, L. et al.  (2017)  Structure, 25(10), pp.1582-1588.

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Keywords:  Topoisomerase IIβ binding protein 1, TopBP1, BRCT5, Bloom syndrome helicase, BLM, pSer-binding pocket, DNA damage mediator, MDC1, phosphopeptide interactions, X-ray crystallography, fluorescence polarization, BRCT

 

Serological Analysis of Tuberculosis in Goats by Use of the Enferplex Caprine TB Multiplex Test.

O'Brien. et al.  (2017)  Clinical and Vaccine Immunology, 24(2), e00518-16.

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Keywords:  tuberculosis, antibodies, goats, Mycobacterium avium subsp. paratuberculosis, Mycobacterium bovis, serologic tests, goat diseases diagnosis, veterinary tuberculosis

 

 

Synthetic melanin bound to subunit vaccine antigens significantly enhances CD8+ T-cell responses.

Carpentier, A.F. et al.  (2017)  PloS one, 12(7), p.e0181403.

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Keywords:  melanin, Dopa, tumor, dermatopathic lymphadenopathy, fungal skin disease, melanosomes, memory CD8+ T-cells, TLR9, ovalbumin, TLR, Ephrin-A2, L-Selectin

 

 

 

PipY, a member of the conserved COG0325 family of PLP-binding proteins, expands the cyanobacterial nitrogen regulatory network.

Labella, J.I. et al.  (2017)  Frontiers in microbiology, 8, p.1244.

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Keywords:  Synechococcus elongatus, nitrogen regulation, cyanobacteria, 2-oxoglutarate receptor, 2-OG, global transcriptional regulator, NtcA, co-activator PipX, signal transducer PII, nitrogen and carbon balance, PlmA, PipY, bicistronic operon pipXY, COG0325 proteins, amino/keto acid homeostasis, PLP-related phenotypes, PLP-holoenzymes, synthetic lethality, cysK, autotrophic growth, GS-GOGAT cycle.

 

 

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity.

Ruiz-Santaquiteria, M. et al.  (2017)  European journal of medicinal chemistry, 135, pp.49-59.

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Keywords:  Peptides, Helix stabilization, Protein-protein interactions, Trypanothione reductase, Leishmania infantum, Cell-penetrating peptides, amide-bridged cyclic peptides, lactam peptides, helical turn, Li-TryR

 

 

Mapping in mice the brain regions involved in the anxiolytic-like properties of α-casozepine, a tryptic peptide derived from bovine α s1-casein.

Benoit, S. et al.  (2017)  Journal of Functional Foods, 38, pp.464-473.

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Keywords:  α-Casozepine, α-CZP, bioactive peptide, milk casein, anxiolytic, c-Fos, marker of neuronal activity, diazepam, benzodiazepine, hippocampus, accumbens nucleus, hypothalamus, amygdala, prefrontal cortex, anxiety-inducing situation, tryptic hydrolysate of bovine αs1 casein, GABA, anxiety

 

 

Protoplast swelling and hypocotyl growth depend on different auxin signaling pathways.

Dahlke, R.I. et al.  (2017)  Plant physiology, 175(2), pp.982-994.

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Keywords:  AtABP1 peptide, Arabidopsis thaliana, transport inhibitor response1, auxin signaling f-box protein, TIR1 / AFB, auxin binding protein1, ABP1, hypocotyl growth

 

 

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.

Bedau, T. et al.  (2017)  Oncotarget, 8(33), p.54873.

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Keywords:  peptide, transendothelial cell migration, inflammation, metastasis, adhesion molecule, CD99, extravasation, metalloprotease, meprin β, pro-inflammatory, lung cancer, proteolytic shedding, Src phosphorylation,

 

 

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

O’Brien, D.P. et al.  (2017)  PLoS biology, 15(12), p.e2004486.

doi l Europe PMC

Keywords:  Calmodulin, response to calcium, adenylate cyclase toxin, CyaA, calmodulin binding, cAMP release, AC conformational disorder, calmodulin-activated enzyme, Bordetella pertussis, virulence factor, CaM, hydrogen/deuterium exchange mass spectrometry, disorder-to-order transition, HDX-MS, SAXS, synchrotron radiation circular dichroism, catalytic loop flexibility, long-range allosteric effects.

 

 

Protective effects of βcasofensin, a bioactive peptide from bovine βcasein, against indomethacininduced intestinal lesions in rats.

Bessette, C. et al. (2016)  Molecular nutrition & food research 60(4), 823-33

doi  l  Europe PMC

Keywords:  Milk bioactive peptide ; Mucus ; Intestinal protection ; Functional food ; Inflammatory bowel disease

 

Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice.

Poosti, F. et al. (2016) Oncotarget, 7(34), pp.54240-54252.

doi  l  Europe PMC

 

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis.
Daskalov, A. et al. (2016) Proceedings of the National Academy of Sciences 113(10), 2720-5.
doi  l  Europe PMC

 

Unraveling flp-11/flp-32 dichotomy in nematodes.
Atkinson, L.E. et al. (2016) International Journal for Parasitology, 46(11), pp.723-736.
doi  l  Europe PMC
Keywords:  FLP-11; FLP-32; FMRFamide-like peptide; Nematode; Neuropeptide; Neuropeptide signalling; flp-11; flp-32

 

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
Hoffmann, S. et al. (2016) The Journal of cell biology 212(1), pp.63-75.
doi  l  Europe PMC
Keywords:  Proliferating Cell Nuclear Antigen ; TRAIP protein, human ; Ubiquitin-Protein Ligases

 

 

(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.
Garcia-Ratés, S. et al. (2016) Neuropharmacology 105, pp.487-499.
doi  l  Europe PMC

 

AMP-activated protein kinase upregulates MAP kinase interacting serine/threonine kinase 1a-dependent phosphorylation of eukaryotic translation initiation factor 4E.
Zhu, X. et al. (2016) Journal of Biological Chemistry, 291(33), pp.17020-17027.
doi  l  Europe PMC

 

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.
Königer, V. et al. (2016) Nature Microbiology, 2, p.16188.
doi  l  Europe PMC

 

Nuclear fallout provides a new link between aPKC and polarized cell trafficking.

Calero-Cuenca, F.J. et al. (2016) BMC biology 14(1), p.32

doi  l  Europe PMC

Keywords:  aPKC; Cell polarity; Cell trafficking; Nuclear fallout

 

Immuno-affinity purification of PglPGIP1, a polygalacturonase-inhibitor protein from pearl millet: studies on its inhibition of fungal polygalacturonases and role in resistance against the downy mildew pathogen.

Prabhu, S. A. et al. (2015) Molecular biology reports 42(6), pp.1123-1138.

doi  l  Europe PMC

Keywords:  Chemical deglycosylation; Confocal immunolocalization; Peptide mass fingerprinting; Plant–pathogen interaction; Quantitative real-time PCR; Two-dimensional gel electrophoresis

 

The structure of the TBCE/TBCB chaperones and α-tubulin complex shows a tubulin dimer dissociation mechanism. 

Serna M et al. (2015)  Journal of Cell Science 128(9), pp. 1824-1834

doi  l  Europe PMC

Keywords: Tubulin; Protein degradation; Chaperones; Folding cofactors; Microtubule

 

EMMPRIN regulates β1 integrin-mediated adhesion through Kindlin-3 in human melanoma cells.

Delyon J et al. (2015) Experimental dermatology, 24(6),  pp. 443-448

doi  l  Europe PMC

Keywords:  EMMPRIN; Kindlin-3; cell adhesion; melanoma; β1 integrin

 

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford A N et al. (2015) Mol cell 57, 1133-1141

doi Europe PMC

 

Identification of a Taraxacum brevicorniculatum rubber elongation factor protein that is localized on rubber particles and promotes rubber biosynthesis.
Laibach N et al. (2015) The Plant J 82, 609-620.

doi Europe PMC

 

Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes.
Pujol-Autonell I et al. (2015) PloS ONE 10.6, e0127057

 doi Europe PMC

 

Influence of Ligands in Metal Nanoparticle Electrophoresis for the Fabrication of Biofunctional Coatings.
Streich C et al. (2015) Appl Surface Sci 348, 92–99

doi Europe PMC

 

Carbon nanotubes and graphene modified screen-printed carbon electrodes as sensitive sensors for the determination of phytochelatins in plants using liquid chromatography with amperometric detection.
Dago A et al. (2015) J Chromatography A 1409, 210–217

doi Europe PMC

 

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.
Ivy JR et al. (2015) PLoS ONE 10.8, e0134620

doi Europe PMC

 

New insight into the structure and function of Hfq C-terminus.
Fortas E et al. (2015) Bioscience Rep 35 (2).

Memory and PTPIP51 - A new protein in hippocampus and cerebellum.
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Signal Transduction by a Fungal NOD-Like Receptor Based on Propagation of a Prion Amyloid Fold.
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The adhesive properties of the Staphylococcus lugdunensis multifunctional autolysin AtlL and its role in biofilm formation and internalization.
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β-Casein(94-123)-derived peptides differently modulate production of mucins in intestinal goblet cells.
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Full membrane spanning self-assembled monolayers as model systems for UHV-based studies of cell-penetrating peptides.
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Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction.
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Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis.
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Escherichia coli Common Pilus (ECP) Targets Arabinosyl Residues in Plant Cell Walls to Mediate Adhesion to Fresh Produce Plants.
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The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.
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Identification of a mitochondrial external NADPH dehydrogenase by overexpression in transgenic Nicotiana sylvestris.
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CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells.
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An ancient oxidoreductase making differential use of its cofactors.
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[The acidic C-terminal tail of the GyrA subunit moderates the DNA supercoiling activity of Bacillus subtilis gyrase.
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A polymerase chain reaction and enzyme linked immunosorbent assay based approach for diagnosis and differentiation between vaccinated and infected cattle with Mycobacterium bovis.
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Arabidopsis Thaliana AXR4 Recombinant Protein Expression for Polyclonal Antibody Production
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Optimising and Evaluating the Characteristics of a Multiple Antigen ELISA for Detection of Mycobacterium bovis Infection in a Badger Vaccine Field Trial.
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A novel tumor suppressor function of Kindlin-3 in solid cancer.
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Polylactide block Polypeptide block Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release.
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Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects.
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The Expression of the Hepatocyte SLAMF3 (CD229) Receptor Enhances the Hepatitis C Virus Infection.
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Signal Peptide Cleavage from GP5 of PRRSV: A Minor Fraction of Molecules Retains the Decoy Epitope, a Presumed Molecular Cause for Viral Persistence.
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The Tll0287 protein is a hemoprotein associated with the PsbA2-Photosystem II complex in Thermosynechococcus elongatus.
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A novel bioactive peptide from yoghurts modulates expression of the gel-forming MUC2 mucin as well as population of goblet cells and Paneth cells along the small intestine.
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The metalloprotease meprin β generates amino terminal truncated Aβ-peptide species.
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Identification and subcellular localization of the soybean copper P1B-ATPase GmHMA8 transporter .
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The lipidation status of acute-phase protein serum amyloid A determines cholesterol mobilization via scavenger receptor class B, type I.
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A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP.
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Microsatellites and RAPD Markers to Study Genetic Relationships Among Cowpea Breeding Lines.
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A novel, mouse mammary tumor virus encoded protein with Rev-like properties.
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Identification of the VirB4-VirB8-VirB5-VirB2 pilus assembly sequence of type IV secretion systems.
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Copper binding to prion octarepeat peptides, a combined metal chelate affinity and immunochemical approaches.
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De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum.
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Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development.
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