Long Active Peptides

Long chain peptide

We routinely prepare long (30-60 aa) to very long peptides up to a maximum length of approximately 100 aa. Because overall yield decreases exponentially with increasing length, synthesis and downstream processing times may increase significantly for longer sequences.

Many peptides of length over 40 aa have raised important research interest and their syntheses remains challenging. We have been manufacturing peptides > 40 aa with consistent high potency biological activity for many years.

Fig 4. (a) Prion peptide with 48 aa (theoretical molar mass 4720) was prepared (50 mg) with a purity level >95% and a sample analyzed by MALDI-TOF MS. Molecular ion at m/z 4721.11.

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Fig 4. (b) Amyloid-β 1-42 peptide with 42 aa (theoretical molar mass 4514) was prepared (25 mg) with a purity level >95% and a sample analyzed by MALDI-TOF MS. Molecular ion at m/z 4517.44.

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Fig 4. ( c ) β-Defensin peptide with 41 aa and 3 disulfide bridge cycles (theoretical molar mass 4282) was manufactured (10 mg) with a purity level >95% and a sample analyzed by MALDI-TOF MS. Molecular ion at m/z 4282.0.

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Ultra-pure peptides (>99% purity level -cell culture grade)

This unique peptide grade includes an additional purification step following standard reversed-phase HPLC elution. It was developed by Genosphere Biotechnologies in collaboration with several research groups using our peptides in cell culture assays. It has been tested with a large number of cell types and exhibits no detectable cytotoxicity commonly associated with standard peptides at higher concentrations.

It has also proven to yield peptides with high activity in sensitive biochemical assays. Another noteworthy feature is a considerably increased stability of the peptides in aqueous solutions.

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